Neurotoxins, including Botox, Dysport, and others, are some of the most popular and effective treatments for reducing wrinkles, fine lines, and other signs of aging. These injectables work by temporarily relaxing targeted muscles, giving the skin a smoother, more youthful appearance. Let’s explore the key neurotoxins used in the U.S., their FDA-approved indications, off-label uses, and the pros and cons of each.
How Neurotoxins Work
Neurotoxins are derived from botulinum toxin, a purified protein that blocks nerve signals to muscles. By inhibiting muscle contractions, neurotoxins effectively reduce dynamic wrinkles—lines that form due to repetitive facial movements.
FDA-Approved Neurotoxins in the U.S.
1. Botox Cosmetic (OnabotulinumtoxinA)
- FDA-Approved Indications:
- Glabellar lines (frown lines between the brows)
- Crow’s feet (lines around the eyes)
- Forehead lines
- Axillary hyperhidrosis (excessive underarm sweating)
- Chronic migraines
- Overactive bladder
- Cervical dystonia (neck muscle spasms)
- Off-Label Uses:
- Lip flip (upper lip enhancement)
- Gummy smile correction
- Jaw slimming (masseter muscle relaxation)
- Bunny lines (nose wrinkles)
- Neck bands (platysmal bands)
- Perioral lines (smoker’s lines)
- Pros:
- Most studied and widely used neurotoxin.
- Predictable, reliable results.
- Versatile with a broad range of applications.
- Cons:
- Slightly higher cost compared to competitors.
- Results can take 5-7 days to become noticeable.
2. Dysport (AbobotulinumtoxinA)
- FDA-Approved Indications:
- Glabellar lines (frown lines)
- Cervical dystonia
- Off-Label Uses:
- Similar to Botox, including crow’s feet, forehead lines, and masseter reduction.
- Pros:
- Diffuses more readily, making it ideal for treating larger areas.
- Results may appear faster (within 2-3 days for some patients).
- Cons:
- Diffusion can be a disadvantage in small, precise areas, potentially causing unintended muscle relaxation.
- Requires slightly more units than Botox for equivalent results.
3. Xeomin (IncobotulinumtoxinA)
- FDA-Approved Indications:
- Glabellar lines
- Cervical dystonia
- Blepharospasm (eyelid spasms)
- Off-Label Uses:
- Crow’s feet, forehead lines, and masseter reduction.
- Pros:
- Contains no additives, reducing the risk of developing resistance or immunity over time.
- Results are comparable to Botox.
- Cons:
- Effects may take slightly longer to set in (5-7 days).
- Some providers find it less versatile than Botox or Dysport.
4. Jeuveau (PrabotulinumtoxinA-xvfs)
- FDA-Approved Indications:
- Glabellar lines
- Off-Label Uses:
- Crow’s feet, forehead lines, and other facial wrinkles.
- Pros:
- Marketed as a “modern” alternative to Botox with similar efficacy.
- Competitive pricing compared to Botox.
- Cons:
- Limited FDA-approved uses compared to other neurotoxins.
- Less long-term data compared to Botox and Dysport.
5. Daxxify (DaxxibotulinumtoxinA-lanm)
- FDA-Approved Indications:
- Glabellar lines
- Off-Label Uses:
- Similar to Botox but not as widely adopted yet.
- Pros:
- Longer duration of results—lasting up to 6 months, which is twice as long as other neurotoxins for many patients.
- Ideal for patients seeking fewer treatments per year.
- Cons:
- Limited availability and higher cost.
- Newer product with less widespread use and clinical data.
Comparing Neurotoxins: Choosing the Right Option
| Neurotoxin | Onset | Duration | Best For | Price Point |
|---|---|---|---|---|
| Botox | 5-7 days | 3-4 months | Precision and versatility | $$ |
| Dysport | 2-3 days | 3-4 months | Larger areas with faster onset | $$ |
| Xeomin | 5-7 days | 3-4 months | Patients prone to resistance | $$ |
| Jeuveau | 5-7 days | 3-4 months | Cost-conscious patients | $ |
| Daxxify | 5-7 days | 4-6 months | Long-lasting results | $$$ |
Weighing the Pros and Cons of Neurotoxins
Pros:
- Quick, Non-Surgical: Minimal downtime and immediate return to daily activities.
- Customizable Results: Treatments are tailored to each patient’s needs.
- Preventative Benefits: Early use can prevent deeper wrinkles over time.
Cons:
- Temporary Results: Maintenance treatments are required every 3-6 months.
- Potential Side Effects: Includes bruising, swelling, or asymmetry if improperly administered.
- Cost: Ongoing treatments can add up over time.
Conclusion: The Right Neurotoxin for You
Each neurotoxin offers unique benefits, and the best choice depends on your specific goals, treatment area, and preferences. It’s essential to consult with an experienced provider to determine the ideal option for your needs.
If you’re ready to explore neurotoxin treatments, schedule a consultation with our office today to learn more about how Botox, Dysport, and other options can help you achieve your aesthetic goals!